MovDisordV3, Main, Exploration, bibRecord, 001082

Investigating Visual Misperceptions in Parkinson's Disease: A Novel Behavioral Paradigm

Identifieur interne : 001082 ( Main/Exploration ); précédent : 001081; suivant : 001083

Investigating Visual Misperceptions in Parkinson's Disease: A Novel Behavioral Paradigm

Auteurs : James M. Shine [Australie] ; Glenda H. Halliday [Australie] ; Mayra Carlos [Australie] ; Sharon L. Naismith [Australie] ; Simon J. G. Lewis [Australie]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0183707

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Hallucination visuelle, Pathologie du système nerveux.

English descriptors

KwdEn :
- Nervous system diseases, Parkinson disease, Visual hallucination.

Abstract

Visual misperception and hallucinations represent a major problem in advanced PD. The pathophysiological mechanisms underlying these symptoms remain poorly understood, with limited tests for their assessment. A recent hypothesis has suggested that visual misperception and hallucinations may arise from disrupted processing in the attentional networks. To assess and quantify visual misperceptions, we developed the novel bistable percept paradigm (BPP), which consists of a battery of "single" and "hidden" monochromatic images that subjects are required to study until they are satisfied that they have recognized everything that the image may represent. In this experiment, 45 patients and 18 age-matched controls performed the BPP. Using an error score value derived from the control group, 23 patients were identified as having significant deficits on the task. Compared to patients who were unimpaired on the task, this group of patients had significantly higher levels of self-reported hallucinations on the SCales for Outcomes in PArkinson's Disease-Psychiatric Complications and also symptoms of rapid eye movement sleep behavior disorder (RBD). Furthermore, impairment on the BPP was associated with significantly reduced performance on an attentional set-shifting task. Patients with impaired performance on the BPP had higher rates of hallucinations, increased symptoms of RBD, and poorer performance on set shifting, suggesting disrupted processing within the attentional control networks. We propose that the BPP may offer a novel approach for exploring the neural correlates underlying visual hallucinations and misperceptions in PD.

Affiliations:

Australie

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000236
to stream PascalFrancis, to step Curation: 002A78
to stream PascalFrancis, to step Checkpoint: 000155
to stream Main, to step Merge: 001134
to stream Main, to step Curation: 001082

Le document en format XML

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<front><div type="abstract" xml:lang="en">Visual misperception and hallucinations represent a major problem in advanced PD. The pathophysiological mechanisms underlying these symptoms remain poorly understood, with limited tests for their assessment. A recent hypothesis has suggested that visual misperception and hallucinations may arise from disrupted processing in the attentional networks. To assess and quantify visual misperceptions, we developed the novel bistable percept paradigm (BPP), which consists of a battery of "single" and "hidden" monochromatic images that subjects are required to study until they are satisfied that they have recognized everything that the image may represent. In this experiment, 45 patients and 18 age-matched controls performed the BPP. Using an error score value derived from the control group, 23 patients were identified as having significant deficits on the task. Compared to patients who were unimpaired on the task, this group of patients had significantly higher levels of self-reported hallucinations on the SCales for Outcomes in PArkinson's Disease-Psychiatric Complications and also symptoms of rapid eye movement sleep behavior disorder (RBD). Furthermore, impairment on the BPP was associated with significantly reduced performance on an attentional set-shifting task. Patients with impaired performance on the BPP had higher rates of hallucinations, increased symptoms of RBD, and poorer performance on set shifting, suggesting disrupted processing within the attentional control networks. We propose that the BPP may offer a novel approach for exploring the neural correlates underlying visual hallucinations and misperceptions in PD.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Investigating Visual Misperceptions in Parkinson's Disease: A Novel Behavioral Paradigm

Investigating Visual Misperceptions in Parkinson's Disease: A Novel Behavioral Paradigm

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri